At the University of Vienna a pilot study assessed the effect of a 3-month folate supplementation with Ocufolin® forte on systemic homocysteine plasma concentration and ocular blood flow in patients with diabetes. Results show that 3 months intake of Ocufolin ® forte is capable of significantly reducing blood homocysteine level in patients with diabetes. In addition, a tendency towards an increase in total retinal blood flow was observed. In diabetic retinopathy, it has been shown that the disease is associated with early retinal vascular dysregulation. “In the later states of the disease, retinal tissue hypoxia is a major trigger of sight-threatening neovascularization. In age-related macular degeneration, there is increasing evidence that reduced blood flow in the choroid is associated with the development and progression of the disease” (Schmidl et al. 2017).